Mechanobiology is an upcoming interdisciplinary field of science where concepts of mechanics, biology and engineering are combined to understand the basics of different cellular processes ranging from cell division to cell differentiation and death.INTENDED AUDIENCE : Biotech/Biosciences/Bioengineering/Physics/Mechanical Engineering/Chemical EngineeringPRE-REQUISITES : B.Sc/B. Tech: Biotech/Biosciences/Bioengineering MSc/M.Tech: Biotech/Biosciences/BioengineeringINDUSTRY SUPPORT :Industries that will recognize this course Academic Institutes, Startups working in the area of tissue engineering
Week 1Lecture 1: Need to study MechanobiologyLecture 2: Cell as a Tent, individual componentsLecture 3: Cell-ECM crosstalkLecture 4: ECM proteins: CollagenLecture 5: Measuring properties of collagen networks
Week 2Lecture 6: Properties of collagen networksLecture 7: RheologyLecture 8: Rheology of biopolymer networksLecture 9: Atomic Force Microscopy (AFM)Lecture 10: Design of protein constructs for AFM
Week 3Lecture 11: Protein unfolding using AFMLecture 12: Protein unfolding using AFMLecture 13: Focal adhesions: focal adhesion proteinsLecture 14: Focal adhesion organizationLecture 15: Focal adhesions: role of forces
Week 4Lecture 16: Cytoskeleton: ActinLecture 17: Force-velocity relationships of actin networksLecture 18: Mesenchymal cell migrationLecture 19: Actin dynamics during mesenchymal migrationLecture 20: Actin dynamics during mesenchymal migration
Week 5Lecture 21: Adhesion Independent MigrationLecture 22: Adhesion Independent & Collective Cell MigrationLecture 23: Collective Cell MigrationLecture 24: Mechanobiology of Stem Cell Fate - ILecture 25: Mechanobiology of Stem Cell Fate - II
Week 6Lecture 26: Mechanobiology of Stem Cell Fate - IIILecture 27: Mechanobiology of Diseases: Cancer ILecture 28: Mechanobiology of Diseases: Cancer IILecture 29: Mechanobiology of Diseases: Cancer IIILecture 30: Mechanobiology of Diseases: Atherosclerosis & Hypertension
Week 7Lecture 31: Mechanobiology of Diseases: Muscular DystrophyLecture 32: Nuclear Mechanotransduction: LINC complexLecture 33: Nuclear Mechanotransduction: LINC complex in cell migrationLecture 34: Nuclear Mechanotransduction: Gene regulationLecture 35: Mechanical Forces & DNA damage
Week 8Lecture 36: Techniques in Mechanobiology: HydrogelsLecture 37: Techniques in Mechanobiology: AFMLecture 38: Techniques in Mechanobiology: Traction Force Microscopy, Trypson Deadhesion & Laser AblationLecture 39: Techniques in Mechanobiology: MicrofabricationLecture 40: Techniques in Mechanobiology: FRE
Prof. Shamik Sen